Person in green shirt pouring two pills from an orange prescription bottle into their hand.

PRISTIQ (desvenlafaxine): Online prescriptions for depression

PRISTIQ (desvenlafaxine) is an SNRI antidepressant used to treat depression symptoms as well as off-label for anxiety and panic disorder. Licensed psychiatric providers at Talkspace can evaluate your symptoms over video and issue an online PRISTIQ prescription if it's the right treatment for you, which can be filled locally or through Amazon Pharmacy.

An initial evaluation by a Talkspace psychiatric provider is required before medication is prescribed. If appropriate, medication will be prescribed for home delivery or for pickup at your local pharmacy. Medication prices are not included in the evaluation price. Talkspace psychiatric providers are unable to prescribe controlled substances and stimulants.

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Here’s how it works

Schedule a video assessment

Answer a few questions online, then meet virtually with a psychiatric provider within a week. Appointments covered by insurance are available for members 18 and older.

Get a diagnosis and prescription

During the appointment, your Talkspace provider will listen to and evaluate your symptoms and, if appropriate, prescribe medication. Build a plan together that feels right.

Begin treatment

Your prescription will be sent to your pharmacy, and you'll have follow-up appointments with the same psychiatric provider. 

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Is PRISTIQ (desvenlafaxine) right for you?

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What is PRISTIQ (desvenlafaxine) used for?

PRISTIQ (desvenlafaxine) is FDA-approved to treat major depressive disorder (MDD) in adults. It’s prescribed to alleviate symptoms associated with depression, including persistent sadness, loss of interest in things and activities once enjoyed, changes in appetite or sleep patterns, and difficulty concentrating. In some cases, providers may also prescribe it off-label to help manage anxiety, panic disorder, or menopausal hot flashes.

Commonly treated with PRISTIQ:

  • Major depressive disorder (MDD)
  • Off-label: Anxiety
  • Off-label: Panic disorder
  • Off-label: Hot flashes during menopause

Who shouldn't take PRISTIQ?

PRISTIQ isn't recommended for people who:

  • Have taken an MAOI within the past 14 days
  • Have uncontrolled narrow-angle glaucoma
  • Have a known hypersensitivity to desvenlafaxine or venlafaxine

What are the side effects of PRISTIQ?

Medication may be prescribed when clinically appropriate based on an evaluation by a licensed healthcare provider.

The most common side effects of PRISTIQ include:

  • Nausea
  • Dry mouth
  • Constipation
  • Decreased appetite
  • Dizziness
  • Excessive sweating
  • Sleep disturbances

If you begin experiencing severe side effects or any unusual changes in behavior after taking PRISTIQ, contact your healthcare provider immediately. You may experience side effects when you first begin taking PRISTIQ that lessen or dissipate once you’ve been taking it for several weeks or months. Treatment results may vary by individual.

Meet the Talkspace licensed providers

Our network of therapists and psychiatric providers have specialization in 150+ conditions, treatment approaches, and mental health needs.

Meet the Talkspace licensed providers

Our network of therapists and psychiatric providers specialize in 150+ mental health conditions and treatment approaches. Get online therapy and medication management on one platform with ongoing care

Depression
Relationships
Anxiety & Stress
Parenting
LGBTQIA+
Chronic Illness
Eating Disorders
OCD
Anger Management
childhood abuse
Mood Disorders
trauma & Grief
Loneliness
Family Conflict
And more...
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Licensed Talkspace provider Elizabeth Keohan, LCSW-C

Elizabeth Keohan, LCSW-C

Licensed Talkspace provider Jill Daino, LCSW-R

Jill Daino, LCSW-R

Chief Medical Officer at Talkspace, Nikole Benders-Hadi

Nikole Benders-Hadi, MD, CMO

Medications we prescribe online

Talkspace psychiatric providers diagnose and treat a wide variety of mental health conditions, including anxiety, depression, ADHD, and others. For some people, their treatment involves medication. Your provider can prescribe you medication if appropriate for your treatment.
Note: Talkspace does not prescribe controlled substances.

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“I found a great therapist on Talkspace and she's noticed that I might be needing some help from a psychiatrist, so she placed a referral. I was able to see a psychiatric ARNP via video visit the next day! I'm definitely on my way to feeling better.

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See a provider today to get a new PRISTIQ (desvenlafaxine) prescription or refill

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Any questions?

Find trust-worthy answers on all things mental health at Talkspace.

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Do you need a prescription for PRISTIQ (desvenlafaxine)?

Yes, if you want to take PRISTIQ, you need a valid prescription from a licensed healthcare provider. Talkspace offers online consultations with licensed psychiatrists and nurse practitioners who can evaluate your condition and symptoms and determine if PRISTIQ is appropriate.

What is PRISTIQ (desvenlafaxine)?

PRISTIQ (also known as the generic, desvenlafaxine) is an FDA-approved antidepressant in the class of drugs known as serotonin-norepinephrine reuptake inhibitors (SNRIs). By increasing levels of serotonin and norepinephrine in the brain, PRISTIQ can reduce depressive symptoms and enhance mood.

Can I get PRISTIQ (desvenlafaxine) online?

Yes — Talkspace provides a convenient way to obtain a prescription for PRISTIQ (desvenlafaxine) online. You just need to schedule a session with a licensed Talkspace psychiatry provider and discuss your symptoms. If they find it suitable, you can receive an online prescription for PRISTIQ.

Can I get PRISTIQ (desvenlafaxine) over the counter?

No, PRISTIQ is not sold over the counter. Like all prescription antidepressants, PRISTIQ requires careful assessment by a qualified healthcare professional who can monitor potential side effects and interactions with other medications.

What is PRISTIQ (desvenlafaxine) used to treat?

PRISTIQ is typically used to treat major depressive disorder (MDD) in adults. It helps alleviate various symptoms of depression, like persistent sadness, loss of interest in activities, and a change in sleep or appetite patterns. In some cases, it may also be used off-label for other mental health conditions, like anxiety and panic disorder.

Can I get a new PRISTIQ prescription or prescription refill from Talkspace?

Yes, you can get a new prescription or prescription renewal for PRISTIQ through Talkspace. Simply schedule a consultation with a licensed Talkspace psychiatry provider. They’ll evaluate your symptoms, discuss your treatment history, and determine whether a new prescription or refill is appropriate for you—all from the comfort of home.

Can I use my health insurance for online PRISTIQ (desvenlafaxine) prescriptions and refills?

Many insurance plans cover Talkspace’s online psychiatry services and prescriptions, including PRISTIQ. Talkspace partners with insurance plans, including but not limited to: 

Online psychiatry coverage can vary, so you should always check with your provider for specifics about your plan. 

How much does PRISTIQ (desvenlafaxine) cost?

The price of PRISTIQ can vary based on several factors, but it’s possible to get it for around $22 per month with discount cards. The cost of PRISTIQ may depend on:

  • Your pharmacy’s location
  • Your insurance coverage
  • Whether you’re using the brand-name PRISTIQ or the generic version, desvenlafaxine
  • Your prescribed dosage

For pricing information, consult your pharmacist or insurance provider.

How do you take PRISTIQ (desvenlafaxine)?

PRISTIQ is generally taken once daily, with or without food. The starting dose is usually 50 mg, but your dosage may be adjusted based on individual needs and severity of symptoms. 

To maximize effects, it’s imperative to:

  • Take PRISTIQ at the same time each day
  • Swallow the tablet whole — do not crush, chew, or split
  • Follow the instructions precisely
  • Never double up on doses if you miss one

If you forget to take your regular dose, take it as soon as you remember. If it’s almost time for your next dose, skip your missed dose and continue with your regular schedule.

Is PRISTIQ (desvenlafaxine) a powerful antidepressant?

PRISTIQ (desvenlafaxine) is a clinically effective antidepressant for treating major depressive disorder. It works by balancing certain brain chemicals to help improve mood, boost energy levels, and enhance overall well-being. While results can vary, many people find relief from symptoms of depression with consistent use under medical supervision.

Disclaimer
Talk to your psychiatrist or healthcare professional about the possible risks and benefits associated with the above medications before starting treatment. It’s up to your psychiatric clinician’s professional judgment whether medication is prescribed. If you are in a life threatening situation – don’t use this site. Call +1 (800) 273-8255 or use these resources to get immediate help.