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Trintellix (vortioxetine): Online prescriptions for depression

Trintellix (vortioxetine) is an antidepressant used to treat major depressive disorder, helping relieve persistent sadness, low energy, and difficulty concentrating. Licensed psychiatric providers at Talkspace evaluate your symptoms over video and issue an online Trintellix prescription if it's the right fit for you, which you can fill locally or through Amazon Pharmacy.

An initial evaluation by a Talkspace psychiatric provider is required before medication is prescribed. If appropriate, medication will be prescribed for home delivery or for pickup at your local pharmacy. Medication prices are not included in the evaluation price. Talkspace psychiatric providers are unable to prescribe controlled substances and stimulants.

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Here’s how it works

Schedule a video assessment

Answer a few questions online, then meet virtually with a psychiatric provider within a week. Appointments covered by insurance are available for members 18 and older.

Get a diagnosis and prescription

During the appointment, your Talkspace provider will listen to and evaluate your symptoms and, if appropriate, prescribe medication. Build a plan together that feels right.

Begin treatment

Your prescription will be sent to your pharmacy, and you'll have follow-up appointments with the same psychiatric provider. 

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Is Trintellix (vortioxetine) right for you?

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What is Trintellix used for?

Trintellix (and its generic form, vortioxetine) is prescribed to help manage symptoms of major depressive disorder (MDD) by improving mood, cognitive function, and emotional well-being. 

A Trintellix prescription can help relieve symptoms like:

  • Persistent sadness or low mood
  • Loss of interest in activities once enjoyed
  • Difficulty concentrating or focusing
  • Trouble making decisions
  • Feelings of worthlessness or excessive guilt
  • Fatigue or low energy
  • Changes in appetite or weight
  • Sleep disturbances (insomnia or oversleeping)
  • Anxiety or restlessness
  • Thoughts of self-harm or suicide

Who shouldn't take Trintellix?

Trintellix isn't recommended for people who:

  • Have taken an MAOI within the past 14 days
  • Have a known hypersensitivity to vortioxetine

What are the side effects of Trintellix?

Common side effects of Trintellix (vortioxetine) include nausea, dizziness, constipation, vomiting, dry mouth, and decreased appetite, which are typically mild and lessen as the body adjusts. Seek immediate medical attention for more serious effects like increased suicidal thoughts (especially in young adults), serotonin syndrome, unusual bleeding or bruising, severe allergic reactions, eye pain, vision changes, and seizures. You may experience side effects when you first begin taking Trintellix that lessen or dissipate once you’ve been taking it for several weeks or months. Treatment results may vary by individual.

If side effects persist or worsen, reach out to your provider to explore dosage adjustments or Trintellix alternatives.

Meet the Talkspace licensed providers

Our network of therapists and psychiatric providers have specialization in 150+ conditions, treatment approaches, and mental health needs.

Meet the Talkspace licensed providers

Our network of therapists and psychiatric providers specialize in 150+ mental health conditions and treatment approaches. Get online therapy and medication management on one platform with ongoing care

Depression
Relationships
Anxiety & Stress
Parenting
LGBTQIA+
Chronic Illness
Eating Disorders
OCD
Anger Management
childhood abuse
Mood Disorders
trauma & Grief
Loneliness
Family Conflict
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Licensed Talkspace provider Elizabeth Keohan, LCSW-C

Elizabeth Keohan, LCSW-C

Licensed Talkspace provider Jill Daino, LCSW-R

Jill Daino, LCSW-R

Chief Medical Officer at Talkspace, Nikole Benders-Hadi

Nikole Benders-Hadi, MD, CMO

Medications we prescribe online

Talkspace psychiatric providers diagnose and treat a wide variety of mental health conditions, including anxiety, depression, ADHD, and others. For some people, their treatment involves medication. Your provider can prescribe you medication if appropriate for your treatment.
Note: Talkspace does not prescribe controlled substances.

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“I found a great therapist on Talkspace and she's noticed that I might be needing some help from a psychiatrist, so she placed a referral. I was able to see a psychiatric ARNP via video visit the next day! I'm definitely on my way to feeling better.

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See a provider today to get a new Trintellix (vortioxetine) prescription or refill

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Any questions?

Find trust-worthy answers on all things mental health at Talkspace.

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Do you need a prescription for Trintellix (vortioxetine)?

Yes, Trintellix (vortioxetine) is only available with a prescription. A licensed healthcare provider must assess your symptoms to determine whether Trintellix is suitable for you.

What is Trintellix (vortioxetine)?

Trintellix (vortioxetine) is an antidepressant used to treat major depressive disorder (MDD). By targeting serotonin levels in the brain, it helps alleviate symptoms like persistent sadness, lack of interest in activities, and difficulty concentrating. With its unique mechanism of action, Trintellix also supports cognitive function, providing a well-rounded approach to managing depression.

Can I get Trintellix (vortioxetine) online?

Yes, after a virtual consultation with a licensed Talkspace provider, you can receive a prescription for Trintellix online to help manage your depression if they judge it appropriate.

Can I get Trintellix (vortioxetine) over the counter?

No, Trintellix is not available over the counter. You will need a prescription from a licensed healthcare provider.

What is Trintellix (vortioxetine) used to treat?

Trintellix (vortioxetine) is FDA-approved to treat major depressive disorder (MDD). By regulating serotonin levels in the brain, Trintellix helps improve mood, cognitive function, and overall emotional well-being.

What are the most common side effects of Trintellix (vortioxetine)?

Common side effects of Trintellix (vortioxetine) may include:

  • Nausea
  • Dizziness
  • Constipation
  • Vomiting
  • Dry mouth
  • Decreased appetite

These side effects are typically mild and tend to lessen as your body adjusts to the medication.

More serious side effects include:

  • Increased risk of suicidal thoughts (especially in young adults)
  • Serotonin syndrome (causes confusion, rapid heart rate, and high fever)
  • Unusual bleeding or bruising
  • Severe allergic reactions (swelling of the face, lips, or tongue)
  • Eye pain
  • Vision changes
  • Seizures

If you experience any concerning side effects after taking Trintellix, contact your healthcare provider immediately.

Can I get a new prescription or prescription refill for Trintellix from Talkspace?

Yes, Talkspace providers can prescribe or refill Trintellix online after a consultation to ensure it’s the right treatment for your symptoms and needs.

Can I use my health insurance for online Trintellix (vortioxetine) prescriptions and refills?

Yes, Talkspace accepts most major insurance plans for online Trintellix prescriptions. However, coverage may vary, so be sure to confirm the details with your insurance provider.

How much does Trintellix (vortioxetine) cost?

The cost of Trintellix can vary depending on factors like insurance coverage, pharmacy pricing, and available discounts. Trintellix is not available in generic form at this time. Without insurance, the price may range from $300 to $500 per month. Manufacturer savings programs, discount cards, and coupons may help reduce the cost significantly.

How do you take Trintellix (vortioxetine)?

Take Trintellix exactly as prescribed by your doctor. It’s typically taken once daily and can be taken with or without food. Do not stop taking Trintellix suddenly, as this can lead to withdrawal symptoms. Also, try to avoid alcohol, as it may worsen side effects such as dizziness or drowsiness.

Why is Trintellix so good?

Trintellix works differently from some other antidepressants because it helps increase serotonin levels in two ways. It not only prevents serotonin from being absorbed too quickly, but it also helps boost serotonin activity directly in the brain. This unique approach can make it more effective for treating depression. Plus, unlike some other antidepressants, Trintellix is less likely to cause weight gain, which makes it a popular choice for people with major depressive disorder (MDD).

How is Trintellix (vortioxetine) different from other antidepressants?

Trintellix works differently from some other antidepressants because it helps increase serotonin levels in two ways. It not only prevents serotonin from being absorbed too quickly, but it also helps boost serotonin activity directly in the brain. This approach may make it more effective for treating depression symptoms in some people.

How long does Trintellix (vortioxetine) take to work?

Trintellix may take several weeks before you notice its full effects. Some symptoms may improve sooner, but it’s important to take it as prescribed and give the medication time to work. Talk with your prescriber if you’re not noticing improvement, or your symptoms are getting worse.

What happens if I miss a dose of Trintellix (vortioxetine)?

If you miss a dose of Trintellix, take it when you remember unless it’s almost time for your next dose. Don’t take two doses at once to make up for a missed dose. If you’re unsure what to do, check with your prescriber or pharmacist.

Disclaimer
Talk to your psychiatrist or healthcare professional about the possible risks and benefits associated with the above medications before starting treatment. It’s up to your psychiatric clinician’s professional judgment whether medication is prescribed. If you are in a life threatening situation – don’t use this site. Call +1 (800) 273-8255 or use these resources to get immediate help.